Down's syndrome with lichen nitidus and segmental vitiligo.

Sir, Down’s syndrome (trisomy 21) is a multisystem disorder with a birth incidence of approximately 1 in 700 live births, making it the most common autosomal chromosomal disorder causing mental retardation. Down’s Syndrome is also associated with an increased incidence of cutaneous disorders.[1-4] In particular, there seems to be an increased incidence of xerosis, atopic dermatitis, seborrheic dermatitis, cutaneous infections, alopecia areata, vitiligo, syringomas, elastosis perforans, keratoderma palmaris et plantaris, and liver manifestations. Retinoids are useful in the treatment of skin and muscle manifestations.[2]